G. Song, Ziwei Zheng, Yanhui Wang
Nov 14, 2016
Citations
0
Influential Citations
18
Citations
Journal
Organic letters
Abstract
A Pd-catalyzed, site-selective p-hydroxyphenyloxylation of benzylic α-C(sp3)-H bonds with 1,4-benzoquinone using thioamide as a directing group is reported. 1,4-Benzoquinone is employed as the p-hydroxyphenyloxy source without extra oxidants. This method exclusively gives site selectivity at α-C(sp3)-H bonds rather than the usual β-C(sp3)-H bonds through C-H activation mode. The reactions proceed with high functional group tolerance in yields of 42-93%.