Alexandre Bruneau, J. Brion, S. Messaoudi
Oct 9, 2014
Citations
0
Influential Citations
8
Citations
Journal
Organic & biomolecular chemistry
Abstract
3-(Heteroaryl)quinolin-2(1H)-ones were synthesized in good to excellent yields using a bimetallic catalytic system through the C-H heteroarylation strategy. Starting from 3-bromoquinolin-2(1H)-ones, various azoles have been successfully used. In all cases, the reactions take place rapidly in dioxane and efficiently proceed in the presence of a bimetallic Pd(OAc)2/CuI as the catalyst, PPh3 as the ligand and LiOtBu or KOAc as the base.