M. V. Goryaeva, S. O. Kushch, Y. Burgart
Nov 1, 2020
Citations
0
Influential Citations
4
Citations
Journal
Russian Chemical Bulletin
Abstract
The peculiarities of the three-component cyclization of ethyl 4,4,4-trifluoroacetoacetate and 1,2-ethanediamines with 3-methylbutan-2-one into hexahydroimidazo[1,2-a]pyridin-5-ones were studied. The reactions proceeded under mild conditions. The use of methyl ketone with a bulky isopropyl substituent increased the stereoselectivity of the transformations, but the reaction with 1,2-diaminopropane was accompanied by the formation 4-[(1-ammoniopropan-2-yl)amino]-1,1,1-trifluoro-4-oxobut-2-en-2-olate as a by-product.