A. Ito, K. Tokawa, B. Shimizu
Oct 17, 1972
Citations
0
Influential Citations
30
Citations
Journal
Biochemical and biophysical research communications
Abstract
Abstract Peptide aldehydes, in which the argininal moiety of leupeptin Ac (Ac-Leu-Leu-argininal) was replaced by phenylalaninal, tyrosinal or tryptophanal, were synthesized. These compounds exhibited potent inhibition on the proteolytic activity of chymotrypsin in contrast with leupeptin which was reported to inhibit trypsin. These results demonstrated a marked relationship between the C-terminal amino aldehyde moiety of these inhibitors and the substrate specificities of chymotrypsin and trypsin. The importance of the aldehyde group for activity was reinvestigated.