J. Brunel, C. Salmi, Y. Letourneux
Jan 10, 2005
Citations
0
Influential Citations
5
Citations
Journal
Tetrahedron Letters
Abstract
Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate reagent (BOP) serves as an efficient and versatile coupling reagent for the coupling of conjugated carboxylic acid with methyl ester amino acids hydrochloride allowing the synthesis of various substituted amino acid derivatives in high chemical yields of up to 90%. The usefulness of this method is illustrated in the synthesis of Fa-Met, an important enzymatic substrate.