C. Marlowe
Mar 1, 1993
Citations
0
Influential Citations
15
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract The trimethylsilylethyl ester group was used as an orthogonal protecting group to perform an on-resin cyclization of a peptide prepared by conventional Fmoc protection strategy. Fmoc-Asp(OTMSE)OH was prepared, incorporated into a peptide, deprotected in the presence of fluoride, cyclized in the presence of BOP, and cleaved from the resin to afford directly a head-to-sidechain cyclic peptide.