Jesús Mosquera, Mateo I. Sánchez, J. Mascareñas
Mar 12, 2015
Citations
0
Influential Citations
24
Citations
Journal
Chemical communications
Abstract
We report a light-sensitive histidine building block for Fmoc/tBu solid-phase peptide synthesis in which the imidazole side chain is coordinated to a ruthenium complex. We have applied this building block for the synthesis of caged-histidine peptides that can be readily deprotected by irradiation with visible light, and demonstrated the application of this approach for the photocontrol of the activity of Ni(II)-dependent peptide nucleases.