K. Yamauchi, M. Kinoshita, M. Imoto
Aug 1, 1972
Citations
0
Influential Citations
29
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
The chemical reactivity of α-aminobenzylphosphonic acid was investigated in order to survey the methods for incorporating aminophosphonic acids into a peptide chain. The investigation revealed that i) a dipeptide analog linked with a phosphonamide bond could be produced by the reaction of C-protected amino acid with the N-protected aminophosphonomonochloridate, and that ii) amino groups of the aminophosphonic acid possessed a reactivity similar to those of amino acids, and were capable of coupling with N-protected amino acids by means of dicyclohexylcarbodiimide.