J. B. Flexner, L. B. Flexner, R. Walter
Jan 31, 1978
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Influential Citations
32
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Quality indicators
Journal
Pharmacology Biochemistry and Behavior
Abstract
The peptide Z-Pro-Leu-Gly-NH2 attenuated puromycin-induced amnesia in mice when administered 5 days prior to training, while arginine vasopressin, lysine vasopressin and cyclo(Leu-Gly), were effective when given 24 hr before training. The activity of all peptides to inhibit puromycin-induced amnesia decreased as the interval after training and before peptide administration increased, suggesting that the peptides influence memory processes rather than generalized arousal mechanisms.