A. Khan, S. Ghosh, Lokman H. Choudhury
May 1, 2006
Citations
1
Influential Citations
57
Citations
Journal
European Journal of Organic Chemistry
Abstract
Perchloric acid adsorbed on silica gel (HClO4/SiO2) has been found to be a highly efficient and versatile catalyst for the Michael addition of thiols to a wide variety of conjugated alkenes such as α,β-unsaturated ketones, carboxylic esters, nitriles, amides and chalcones in dichloromethane or methanol at room temperature. The reactions are completed within 2–20 min in high yields. Some of the additional advantages are: no aqueous work-up is necessary, and the catalyst is also reusable. Moreover, the solid product can be obtained without chromatographic separation. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)