Xuliang Zhuan
2012
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Quality indicators
Journal
Journal of Soochow University
Abstract
Objective To study the effect of nimodipine on learning and memory of rat model of Alzheimer's disease(AD) and to explore its effect on the expression of connexin 43(Cx 43).Methods 30 Sprague-Dawley rats were selected and randomly divided into 3 groups: control,AD,and nimodipin group.The rat AD model was established by stereotactically injecting amyloid beta protein(Aβ) 25-35 into the bilateral ventricles.Learning and memory functions were tested using the Y-type electric maze.The expression of hippocampal Cx43 was tested by western blot.Results Compared with the AD group,the number of correct reaction in Y maze increased after nimodipine treatment.Nimodipine could decreased the Cx 43 expression which was proved to be elevated in hippocampus of AD rat.Conclusion Nimodipine can improve the learning and memory ability of AD rat,which may be related to its downregulation of Cx43.