Natsuki Tanokashira, S. Kukita, H. Kato
Sep 1, 2016
Citations
1
Influential Citations
26
Citations
Journal
Tetrahedron
Abstract
Abstract We isolated 16 new xestoquinone derivatives, including two trimers, six dimers, and four monomers with containing thiomorpholine 1,1-dioxide and pyrrolidine-2,4-diol moieties, from the marine sponge Petrosia alfiani and determined their structures including the absolute configurations using computational methods. They exhibited potent inhibitory activities against USP7 with IC50 values in the range of 0.13–2.0 μM.