V. Habernickel
Jul 1, 2003
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Journal
Arzneimittelforschung
Abstract
2-Substituted-5-thienyl-benzyl-isopropoxy-fluorophenoxy-ethylamine derivatives X = H, F, OH or OCH3. The compounds are anti-dopaminergic agents, useful for treating schizophrenia, dependency and neurodegenerative disorders. The activity of the compounds includes also neuroleptic, neuroprotective and antiaddictive activity. The use is especially claimed for treating schizophrenia. Example for activity and synthesis is the compound [3-(3-thienyl)-benzyl]-[2-([5-fluoro-2isopropoxy-]-phenoxy)ethyl]-amine. PCT-WO 2000 58 282; Int Cl.: C 07 D. Pierre Fabre Medicament SA, Paris (FR) Ind.: [144] 7 (2003)