Zhi-min Li, T. Kamon, D. Personett
Feb 1, 2012
Citations
0
Influential Citations
12
Citations
Journal
MedChemComm
Abstract
Agelastatin A (AA) is an anti-neoplastic agent with anti-osteopontin (OPN) activity. Brain tumors often express OPN significantly. A comprehensive chemoinformatic analysis followed by in vivo pharmacokinetic evaluations in mice is performed. CNS penetration of AA is about 10%. AA should be further tested for activity against brain tumors.