Yang Rui
2011
Citations
0
Influential Citations
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Citations
Quality indicators
Journal
The Chinese Journal of Clinical Pharmacology
Abstract
Objective To study the pharmacokinetics of aspirin magnesium and aluminium capsules in healthy volunteers.Methods Thirty subjects were randomized into 3 groups and administered by single oral dose of 81,162,324 mg or multi oral dose of 162 mg for 7 days.Concentrations of aspirin and salicylic acid in plasma were determined by LC-MS/MS.The main pharmacokinetic parameters were calaulated.Results The main pharmacokinetic parameters of aspirin single and multi were as follows:Cmax were(0.91±0.35),(1.82±0.61),(2.95±1.38) mg·L-1 and(2.17±0.79) mg·L-1;t1/2 were(0.32±0.08),(0.40±0.09),(0.38±0.10) h and(0.39±0.11) h;AUC0-t were(0.64±0.13),(1.66±0.55),(2.51±0.84) mg·h·L-1 and(1.65±0.44) mg·h·L-1.The main pharmacokinetic parameters of salicylic acid single and multi were as follows:Cmax were(4.61±0.41),(8.44±2.06),(15.98±1.86) mg·L-1 and(11.36±2.01) mg·L-1;t1/2 were(2.18±0.84),(2.55±0.93),(2.51±0.58) h and(2.60±0.74) h;AUC0-t were(16.34±5.04),(43.55±22.71),(85.56±25.55) mg·h·L-1 and(57.37±21.89) mg·h·L-1.Conclusion The process of aspirin magnesium and aluminium capsules in the dosage range of 81-324 mg fit linear dynamic feature and without clearly cumulation in the continuous administration manner.