E. Molden, P. W. Johansen, Grethe Helen Bøe
Sep 1, 2002
Citations
3
Influential Citations
52
Citations
Quality indicators
Journal
Clinical Pharmacology & Therapeutics
Abstract
Recently, it was shown in vitro that the polymorphic enzyme cytochrome P450 (CYP) 2D6 mediates O‐demethylation of diltiazem. The aim of this study was to compare the pharmacokinetics of diltiazem and its major metabolites in healthy human volunteers representing different CYP2D6 genotypes.