Yoshihiko Ito, Masaki Ogoda, Ryo Niiya
2011
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Journal
Neurourology and Urodynamics
Abstract
Hypothesis / aims of study Imidafenacin, a novel antimuscarinic agent, is currently developed for the therapy of overactive bladder (OAB) in Japan. It was reported that imidafenacin exhibited functional selectivity for the bladder over the salivary gland and even high doses of this drug had little pharmacological effect on the central nervous system (CNS) [1-3]. The present study was aimed to clarify the underlying mechanism for bladder selectivity on the basis of in vivo muscarinic receptor (mAChR) binding of oral administration of imidafenacin in rats in relation to the pharmacokinetics. We characterized muscarinic receptor binding in various tissues and pharmacokinetics in rats after oral and intravesical administration of imidafenacin.