H. Norbury, R. Franklin, P. Marrott
2004
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0
Influential Citations
4
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Quality indicators
Journal
European Journal of Clinical Pharmacology
Abstract
SummaryThe pharmacokinetics of indoramin (Baratol®) have been studied in five male and five female healthy, middle-aged volunteers after intravenous administration (0.14 mg/kg). Elimination occurred in an apparently biexponential fashion with a mean elimination half-life of 4.0h (±0.25 SEM). The mean plasma clearance was 19.9 ml/min/kg (±1.32 SEM) and the mean volume of distribution 7.4 l/kg (±0.81 SEM). There were no significant differences in these parameters between male and female volunteers. Protein binding of indoramin ranged from 85.6% at 81 ng/ml to 72.2% at 129 µg/ml. Two classes of binding site were evident, with affinity constants of 6.85×104M−1 and 4.30×103M−1.