Dai Bin
2011
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Journal of Clinical Rational Drug Use
Abstract
Objective To investigate the clinical pharmacokinetics and metabolites of Azasetron Hydrochloride after intravenous infusion in healthy volunteers.Methods Azasetron Hydrochloride for injection were given to 15 healthy volunteers of a dose of 10 mg,the concentrations of Azasetron Hydrochloride in human plasma and rine were determined by HPLC,the main pharmacokinetic parameters ere calculated.Results The ain pharmacokinetic parameters of Azasetron Hydrochloride ere as the followings:AUC0-t(63.37±13.02)(mg/L)h,AUC0-∞(51.89±11.84)(mg/L)h,Cmax(7.125±0.591) mg/L,Tmax(0.667±0.249)h.12 percent of Azasetron Hydrochloride were discharged by urine.Conclusion Azasetron Hydrochloride was speedy absorbed and distributed in vivo,The efficacy was obvious.