Zhang Juan-hong
2013
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Pharmaceutical Journal of Chinese People's Liberation Army
Abstract
Objective To investigate the pharmacokinetics of methazolamide in rats after acute exposure to high altitude.Methods Methazolamide tablets of 0.0049 g were intragastrically administered to rats in low altitude(~50 m) and exposure to high altitude(~4100 m) groups.Blood samples were collected from veins of eye sockets into heparinized centrifuge tubes at 0,0.083,0.25,0.5,0.75,1,1.5,2,4,6,8,12 and 24 h after administration.Plasma concentration of methazolamide was determined by LC-MS/MS.Results Pharmacokinetic parameters of methazolamide at low altitude were significantly different from those of acute exposure to high altitude.Comparison of the t1/2 obtained in plasma in the two groups found a decrease from(6.725±0.406) to(2.61±0.715) h after acute exposure to high altitude.The MRT was lower than in the low-altitude group.Cmax was significantly higher in the acute-exposure-to-high-altitude group than in the low altitude group.Conclusion This study has found significant changes in the metabolism of methazolamide in rats after acute exposure to high altitude,which could be of therapeutic importance.This finding may provide some references for clinical rational use of methazolamide at low altitude and after acute exposure to high altitude.