Mao Li-jun
2010
Citations
0
Influential Citations
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Citations
Quality indicators
Journal
The Chinese Journal of Clinical Pharmacology
Abstract
Objective To study pharmacokinetics of mitiglinide calcium tablets in Chinese healthy volunteers.Methods Thirty healthy volunteers were randomly divideded into three groups with 5 males and 5 females in each group.The volunteers in three groups were administrated with single dose of mitiglinide calcium tablets 5,10,20 mg respectively.The concentrations of mitiglinide in human plasma were determined by LC-MS/MS.The main pharmacokinetic parameters were calculated by DAS2.0 software.Results The main pharmacokinetic parameters of the volunteers who were administrated with a single dose of 5,10,20 mg were as follows: tmax were(0.44±0.22),(0.57±0.33)and(1.50±0.53) h;Cmax were(578.96±119.30),(834.98±202.02) and(1337.93±542.13) μg·L-1;AUC0-t were(815.97±196.21),(1535.78±403.10) and(3624.79±1053.75) μg·h·L-1;AUC0-∞ were(827.54±204.97),(1560.56±418.55) and(3710.05±1066.10) μg·h·L-1;t1/2分别为(1.15±0.25),(1.32±0.09)and(1.29±0.25) h,respectively.Conclusion The pharmacokinetics of mitiglinide fit the linear dynamic feature in the doseage range of 5 to 20 mg in Chinese healthy volunteers.