E. Randinitis, J. Brodfuehrer, A. Vassos
Oct 1, 1999
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Drugs
Abstract
Clinafloxacin is an extremely potentmember of the quinolone class of synthetic antimicrobial agents. Compared with other available quinolones, clinafloxacin usually requires lower drug concentrations for bacterial inhibition and is active against a broader spectrum of organisms. It is effective against many multiple drug-resistant organisms and is active against many known quinolone-resistant strains. Clinafloxacin is being studied primarily in hospitalised adults for the treatment of serious and potentially life-threatening infections, including nosocomial and community-acquired pneumonia, febrile neutropenia, complicated intra-abdominal infections, complicated skin and soft tissue infections, endocarditis and acute gynaecological infections. Studies were conducted to evaluate the safety, tolerability and pharmacokinetics of oral and intravenous clinafloxacin in the 25 to 400mg single and multiple dose range, to determine the absolute bioavailability of the drug, and to determine the contribution of intraand inter-individual variability to the overall variation in pharmacokinetics.