Jevgenij A. Raskatov, Amanda E. Hargrove, Alex Y So
May 9, 2012
Citations
1
Influential Citations
30
Citations
Quality indicators
Journal
Journal of the American Chemical Society
Abstract
The pharmacokinetic properties of three pyrrole-imidazole (Py-Im) polyamides of similar size and Py-Im content but different shape were studied in the mouse. Remarkably, hairpin and cyclic oligomers programmed for the same DNA sequence 5'-WGGWWW-3' displayed distinct pharmacokinetic properties. Furthermore, the hairpin 1 and cycle 2 exhibited vastly different animal toxicities. These data provide a foundation for design of DNA binding Py-Im polyamides to be tested in vivo.