A. Sparreboom, H. Gelderblom, S. Marsh
Jul 1, 2004
Citations
5
Influential Citations
251
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Quality indicators
Journal
Clinical Pharmacology & Therapeutics
Abstract
The adenosine triphosphate–binding cassette transporter ABCG2 (breast cancer resistance protein [BCRP]) functions as an efflux transporter for many drugs, including the topoisomerase I inhibitor diflomotecan, and is expressed at high levels in the intestine and liver. We performed an exploratory analysis to evaluate the effects of the natural allelic variant ABCG2 421C>A on the pharmacokinetics of diflomotecan.