W. B. Bass, J. Gray, E. Larson
Jul 1, 1959
Citations
0
Influential Citations
2
Citations
Journal
Toxicology and applied pharmacology
Abstract
Abstract Pharmacologic and toxicopathologic studies of 1-methyl-5-phenylpyrazolidin-3-one (U-6373) are described. This agent exhibited promising anticonvulsant activity in the animal tests employed. Toxic manifestations of this compound in the hematopoietic tissues and liver of the rat and dog, however, precluded its clinical trial in man. The occurrence of these manifestations in animals has not frequently been reported for other anticonvulsant drugs.