H. Meent, A. Geurts, J. Limbeek
Apr 1, 2003
Citations
0
Influential Citations
31
Citations
Quality indicators
Journal
Topics in Stroke Rehabilitation
Abstract
Abstract Clinical question/objective: A systematic evaluation of the literature published from 1966 until December 2001 on pharmacologic interventions for poststroke depression (PSD). Design: Articles were selected from a computer-based search and were independently reviewed by three evaluators using a standardized criteria including internal validity items as well as descriptive and quantitative items. Results: Fifty studies were preliminarily reviewed and 10 randomized controlled trials (RCTs) were included for systematic analysis. Conclusion: Selective serotonin reuptake inhibitors (citalopram and fluoxetine) may be effective in the treatment of PSD. There is some evidence for a beneficial effect of the tricyclic antidepressant nortriptyline, however, the RCTs for this medication lack sufficient validity, and reports on side effects are contradictory.