I. Iriepa, B. Gil-Alberdi, E. Gálvez
Jun 10, 1995
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Influential Citations
7
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Journal
Journal of Molecular Structure
Abstract
Abstract A series of some esters derived from 3-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9β-ol were synthesized and studied by 1H and 13C NMR spectroscopy, and the crystal structure of 3-methyl-2,4-diphenyl-9β(3,5-dimethyl-benzoyloxy)-3-azabicyclo[3.3.1]nonane (II) has been determined by X-ray diffraction. The compounds studied display, in deuterochloroform, a flattened chair-chair conformation with the cyclohexane ring more flattened than the piperidine moiety and the NCH3 groups in equatorial position. Pharmacological assays on mices were drawn to evaluate drug-induced behavioral alteration, peripheral or central acute toxicity analgesic and neuroleptic activity.