M. Shapero, P. Southgate
Feb 1, 1970
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0
Influential Citations
4
Citations
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Journal
British Journal of Pharmacology
Abstract
1 . The intravenous, subcutaneous and oral toxicity of ambenoxan in mice is reported. 2 . Ambenoxan is a centrally acting skeletal muscle relaxant shown to be effective in mice, rats, rabbits, dogs and monkeys without loss of the righting reflex. 3 . It had no peripheral neuromuscular blocking properties. 4 . Decerebrate rigidity was depressed or abolished in the rabbit. 5 . The effects of strychnine, leptazol, or tremorine were not antagonized. 6 . In common with other depressants of the central nervous system, ambenoxan prolonged the sleeping time of hexobarbitone. 7 . Ambenoxan had no local anaesthetic properties. 8 . In the anaesthetized cat the drug lowered the blood pressure and reduced the pressor response to adrenaline but not to noradrenaline.