S. G. Farmer, R. Burch
1992
Citations
8
Influential Citations
203
Citations
Quality indicators
Journal
Annual review of pharmacology and toxicology
Abstract
Bradykinin (BK; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) is a potent in flammatory peptide whose generation in tissues and body fluids elicits numer ous responses including vasodilation, edema, smooth muscle spasm, as well as pain and hyperalgesia via stimulation of Cand A-fibers. There is sub stantial evidence that BK and related kinins, such as kallidin (Lys-BK, or KD), contribute to the inflammatory response in acute and chronic diseases including allergic reactions, arthritis, asthma, sepsis, viral rhinitis, and in flammatory bowel diseases. The past few years have witnessed an abundance of reviews on regulation of the biosynthesis, release, and degradation of kinins, in addition to their physiological and pathophysiological effects (1-13). Here we highlight recent advances in our understanding of biochemical and molecular aspects of kinin receptor pharmacology.