N. Back, J. Ambrus, H. Velasco
May 1, 1962
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Journal
Clinical Pharmacology & Therapeutics
Abstract
Spiramycin, an antibacterial chemotherapeutic agent, was found effective against a series of transplantable rodent tumors and neoplastic tissue culture lines. Acute and subacute toxicity was studied in mice and dogs. Large intravenous doses produced hypotension, increased intestinal motility, hyperactivity, increased neuromuscular irritability, salivation, and retching or vomiting in dogs. Animals which died after daily intravenous injections of large doses showed lymphoid involution, inhibition of mitosis, and degenerative changes in the intestinal epithelium, respiratory tract, liver, pancreas, salivary glands, and proximal renal tubules. There was no significant bone marrow depression.