T. Haley, F. Cartwright
Feb 1, 1968
Citations
1
Influential Citations
12
Citations
Quality indicators
Journal
Journal of pharmaceutical sciences
Abstract
A pharmacologic and toxicologic investigation of potassium perrhenate and rhenium trichloride showed that these compounds exhibited the same delayed acute toxicity previously reported for other rare elements. Rhenium trichloride was 10 times more toxic than potassium perrhenate but the latter compound was among the least toxic of all of the rare inorganic compounds studied. Potassium perrhenate was not irritating to the eyes and rhenium trichloride produced only a minimum of such irritation. Neither compound was irritating to the skin. Potassium perrhenate had no effect on isolated intestine while the liberation of acid from rhenium trichloride caused an intestinal spasm. Potassium perrhenate caused death by cardiovascular collapse coupled with respiratory failure. The compound also affected the superior cervical ganglion. Decomposition of aqueous solutions of rhenium trichloride and their extreme acidity prevented any pharmacodynamic studies.