Steven Susanto, N. Jung, S. Bräse
Apr 20, 2016
Citations
0
Influential Citations
2
Citations
Journal
RSC Advances
Abstract
2-Mercaptobenzoimidazoles are an important class of heterocycles showing biological activity in diverse therapeutic applications. In the presented study, a strategy for the syntheses of substituted 2-mercaptobenzoimidazoles on solid supports is shown. After immobilization of the benzoimidazole core on a functionalized resin and its modification via the Mitsunobu reaction, the target 2-mercaptobenzoimidazoles are cleaved either via transesterification or aminolysis giving functionalized S,N-dialkylated mercaptobenzoimidazoles.