Anita R. Banpurkar, Sachin S. Wazalwar, F. Perdih
Jul 21, 2018
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Influential Citations
9
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Journal
Bulletin of the Chemical Society of Ethiopia
Abstract
3-Methyl-4 H -isoxazol-5-one was synthesized at room temperature by simple stirring method from ethyl acetoacetate and hydroxylamine hydrochloride in aqueous medium and coupled with diazotized substituted amine to form series of 4-(substituted phenylazo)-3-methyl-4 H -isoxazol-5-ones through green chemistry. All the compounds formed were characterized by IR, 1 H and 13 C NMR spectroscopy, MS and elemental analysis. Crystal structure of novel 4-(4-fluorophenylazo)-3-methyl-4 H -isoxazol-5-one was determined by the X-ray diffraction. Antibacterial and antifungal activity was studied against Escherichia coli , Pseudomonas aeruginosa , Staphylococcus aureus , Staphylococcus pyogenus and Candida albicans , Aspergillus niger , Aspergillus clavatus , respectively. All synthesized compounds were found to be active against a gram-positive bacterium Staphylococcus aureus . Two compounds showed antifungal activity against Candida albicans close to standard greseofulvin. KEY WORDS : Azo dyes, Substituted amines, Antibacterial and antifungal activity, X-ray diffraction, Spectroscopy, Green chemistry Bull. Chem. Soc. Ethiop. 2018 , 32(2), 249-257. DOI: https://dx.doi.org/10.4314/bcse.v32i2.6