Fu Ming-Kun, Wu Xian, N. Jun
Jul 1, 2005
Citations
0
Influential Citations
1
Citations
Journal
Chinese Journal of Chemistry
Abstract
To implement the solid phase synthesis of 4″-epi-methylamino-4″-deoxyavermectin B1 benzoate, tert-butyl- dimethylsilylchloride was chosen for the first solution synthesis. Then a novel silyl chloride resin 1, achieved from hydroxymethyl polystyrene resin and dimethyldichlorosilane, was used successfully for the attachment of avermectin B12. Through oxidation, amination formation, cleavage, and benzoate formation, resin bounded avermectin B19 gave 4″-epi-methylamino-4″-deoxyavermectin B1 benzoate 6.