V. Fauchet, L. Bourel, A. Tartar
Nov 10, 1994
Citations
0
Influential Citations
7
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
The synthesis of trypanothione disulide 1 was performed according to an original solid phase strategy. The key step involves the selective protection of the primary amines of spermidine with tertiobutyldiphenylsilyl chloride followed by coupling the disilyl derivative on a methylchloroformylated polystyrene resin. After deprotection and assembly of the peptidic chain, treatment of the resin with HF, followed by oxidation and purification affoded 1 in 38% yield.