Ankita Chakraborty, Avula Shiva Krishna, G. Sheelu
Aug 16, 2022
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Journal
Organic & biomolecular chemistry
Abstract
An environmentally benign, cost-effective and scalable process for the preparation of both the enantiomers of 3-hydroxytetrahydrofuran has been developed. pH-Controlled ring opening of enantiomerically pure epichlorohydrins with cyanohydrin is the key step of the process. The entire protocol does not require any column purification.