A. Furst, C. Klausner, W. Cutting
Sep 19, 1959
Citations
0
Influential Citations
7
Citations
Quality indicators
Journal
Nature
Abstract
PHENAZINE di-N-oxide has been found to be a carcinostatic agent for the Ehrlich ascites tumour. More than 90 per cent of tumour-bearing animals treated with this compound intraperitoneally survived 30 days or more, and were then free of tumours as compared with an average 13-day survival of the untreated control group. A comparison of this agent with other drugs active against this tumour reveals that 6-mercaptopurine, administered intraperitoneally1, or N-methylformamide, given orally2, extended mean survival time by 25–100 per cent, but that all animals died with ascites tumour. Other phenazine compounds, like the dye janus green B3 have been reported to have activity against a transplanted mouse tumour, but only at toxic levels.