J. Bálint, Gabriella Egri, V. Kiss
Jan 21, 2002
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0
Influential Citations
18
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract 6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) was resolved in several different solvents by tartaric acid derivatives as the most common acidic resolving agents available in industrial quantities. Strong reaction kinetics and solvent dependence were observed, curiously without solvation. In possession of these findings, an economic resolution process is proposed, which is completed by the incorporation of a racemization step.