J. Catalano, V. Gaitonde, M. Beesu
Oct 28, 2015
Citations
0
Influential Citations
7
Citations
Journal
Tetrahedron Letters
Abstract
We have discovered a 3-bromo-7-phenoxypyrazolo[1,5-a]pyrimidine intermediate that allows for the direct sequential funtionalization of the 3-position and 7-position of a pyrazolo[1,5-a]pyrimidine scaffold. The intermediate and general method described herein offer an improvement over prior methods, particularly in cases where multiple unique 3-aryl substituents are to be incorporated in conjunction with multiple unique 7-amino substituents.