F. Ragaini, F. Ferretti, Manar Ahmed Fouad
Nov 18, 2022
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The 26th International Electronic Conference on Synthetic Organic Chemistry
Abstract
: The reductive cyclization of different organic nitro compounds by carbon monoxide, catalyzed by transition metal complexes, is a very efficient and clean strategy for the synthesis of many N -heterocycles. However, it requires the use of autoclaves and pressurized CO lines. In this paper, the authors will present the results obtained in their laboratories on the use of phenyl formate as a convenient CO surrogate, able to liberate carbon monoxide under reaction conditions and allowing for the use of a cheap glass pressure tube as a reaction vessel. In most cases, yields were better than those previously reported using pressurized CO, proving that the use of CO surrogates can be a viable alternative to the gaseous reagent.