Q. S. Wang, J. N. Zhou, T. Xu
Mar 1, 2001
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0
Influential Citations
3
Citations
Quality indicators
Journal
Acta pharmacologica Sinica
Abstract
AIM To study the effect of phenylmethylsulfonyl fluoride (PMSF), a phospholipase C inhibitor, on ischemic injury to brain mitochondria in rats. METHODS The phospholipid level, membrane fluidity, and respiratory control ratio of brain mitochondria were measured. The effect of phenylmethylsulfonyl fluoride was tested. RESULTS The phospholipid level, membrane fluidity, and respiratory control ratio of brain mitochondria in ischemia group decreased but increased in the PMSF treatment group (P < 0.05). CONCLUSION PMSF ameliorated ischemic injury to brain mitochondria in rats.