Ajit K. Ghosh, Saeed Khan, D. Farquhar
1999
Citations
1
Influential Citations
14
Citations
Journal
Chemical Communications
Abstract
4-(β-D-Galactopyranosyl)benzyl N,N,N′,N′-tetrakis(2-chloroethyl)phosphorodiamidate 1 was facilely biotransformed to the alkylating antitumor agent, N,N,N′,N′-tetrakis(2-chloroethyl) phosphorodiamidic acid, 4, when incubated with E. coli β-galactosidase, and therefore has potential for use in conjunction with gene-directed enzyme prodrug therapy.