E. Pedersen, D. Carlsen
1977
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0
Influential Citations
1
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Journal
ChemInform
Abstract
Abstract 2-Acetamido-3-thiophenecarboxylic acid ethyl esters 1 have been heated in HMPT to reflux temperature to produce 4,6-bis(dimethylamino)thieno[2,3-b]pyridines 7 . Substituents in the 4 position of the thiophene ring were found to exert steric hindrance on the reaction. Only a multistep mechanism can account for the product 7 . The intermediates 2–5 were also isolated in the reaction of 1a with HMPT.