R. Jeon, P. Wender
Feb 1, 2001
Citations
0
Influential Citations
6
Citations
Journal
Archives of Pharmacal Research
Abstract
Abstract4′-Bromoacetophenone analogs, which are able to generate monophenyl radicals capable of hydrogen atom abstraction, were investigated as possible photoinducible DNA cleaving agents. The potential of 4′-bromoacetophenone as a possible new DNA cleaver is explored. Pyrrolecarboxatmid conjugated 4′-bromoacetophenones, in particular, DNA cleaving activity and sequence-selectivity on the contiguous AT base pair sites.