Jiang Wang, Theresa H. Nguyen, N. Zheng
Jan 7, 2016
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0
Influential Citations
7
Citations
Journal
Science China Chemistry
Abstract
Continuous flow has recently emerged as a powerful enabling technology that greatly improves many reactions’ efficiency. Here, we apply the technology to intermolecular [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes by photoredox catalysis. An across-the-board improvement in the annulation’s efficiency is noticed. Moreover, a gram-scale annulation is successfully demonstrated in continuous flow using a much lower catalyst loading.