Roberto V. Antunes, H. Batista, R. Srivastava
Nov 1, 1998
Citations
0
Influential Citations
54
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
Seven new phthalimide derivatives (9a-g) with 1,2,4-oxadiazol-5-yl methyl group attached to nitrogen have been synthesized from N-phthaloylglycine 6 and arylamidoximes 7a-g. All of these showed potent analgesic effect with acetic acid induced "writhing" test in mice. One of the better compounds (ID50 = 2.2 mg/Kg i.p.) has been found to be 9a which also demonstrates analgesic activity against inflammatory pain.