T. Aalto, M. Firman, N. Rigler
Aug 1, 1953
Citations
5
Influential Citations
118
Citations
Quality indicators
Journal
Journal of the American Pharmaceutical Association. American Pharmaceutical Association
Abstract
The history of the esters of p-hydroxybenzoic acid and their uses as preservatives in pharmaceuticals, cosmetics, foods, and industrial products are discussed. Antimicrobial studies show that the methyl, ethyl, propyl, and butyl esters are effective in low concentrations against fungi and Gram-positive bacteria, but less effective against Gram-negative bacteria. The esters are more fungistatic than fungicidal. The p-hydroxybenzoates were also tested against microorganisms in the presence of humans serum, and against the growth of A. niger in procaine nicillin suspensions. The physical and chemical proprties of the p-hydroxygnwates are extensively described, as well as methods of incorporation and a method of determination by ultraviolet absorption.