K. Sugimoto, T. Akiyama, Nobutaka Shimizu
May 8, 2015
Citations
0
Influential Citations
12
Citations
Quality indicators
Journal
Research and Reports in Urology
Abstract
Aim To investigate the clinical efficacy of acotiamide hydrochloride hydrate in patients with detrusor underactivity. Methods We measured the post-void residual urinary volume in 19 patients with underactive bladders. All these patients had been under treatment with distigmine bromide and were prescribed acotiamide hydrochloride hydrate at a dose of 100 mg three times daily for 2 weeks. Results Compared with the post-void residual urinary volume value at baseline (161.4±90.0 mL) a statistically significant reduction was observed at the end of treatment (116.3±63.1 mL) (P=0.006). The drug was generally well tolerated by the majority of patients. Conclusion Maybe, acotiamide hydrochloride hydrate showed clinical efficacy in patients with underactive bladders and may, therefore, be used alternatively in patients who do not respond sufficiently to distigmine bromide.