K. Wen
1958
Citations
0
Influential Citations
0
Citations
Journal
Acta Chimica Sinica
Abstract
Two series of piperazines, namely α, ω-bis (1-substituted-4-piperazyl)alkanes hydrochlorides and 1, 2-bis (1'-substituted-4'-piperazyl ethoxy) ethanehydrochlorides, have been prepared for the purpose of screening their chemo-therapeutic activity toward Schistosomiasis Japanica in experimentally infectedanimals. α, ω-Bis (1-carbethoxy-4-piperazyl) alkanes and α, ω-bis (1-diethylcarba-myl-4-piperazyl) alkanes have been prepared from 1-substituted piperazinesand the corresponding α, ω-dibromo-alkanes in the presence of sodium bicar-bonate. α, β-Bis (β-chloroethoxy) ethane was treated with sodium iodide, thenreacted with the appropriate 1-substituted piperazine and sodium bicarbonateto form 1, 2-bis (1'-carbethoxy-4'-piperazylethoxy)ethane and 1, 2-bis (1'-diethylcarbamyl-4'-piperazylethoxy) ethane respectively. The 1-methyl piperazine derivatives of these two series were preparedfrom excess of 1-methylpiperazine and corresponding α, ω-dibromo-alkanes orα, β-bis (β-chloroethoxy) ethane in dried benzene solution.