Y. Tung
1957
Citations
0
Influential Citations
0
Citations
Journal
Acta Chimica Sinica
Abstract
Seven 1-methyl-4-(alkoxyphenyl thiocarbamyl)piperazine hydrochlorides and three alkylene diacyl-di-(1-methyl piperazide) hydrochlorides have been prepared for testing their activity against schistosomiasis in experimental animals, which were infected with Schistosoma Japonica.1-Methyl-4-(alkoxyphenyl thiocarbamyl) piperazines are synthesized from 1-methyl piperazine and corresponding alkoxyphenyl isothiocyanates in ethereal solution. By the action of 1-methyl piperazine with the appropriate dibasic acid chlorides in benzene solution, the alkylene di-acyl-di-(1-methyl piperazides) are obtained.The hydrochlorides are formed by passing hydrogen chloride into dried ethereal or acetone solution of corresponding bases respectively.